| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE8B (1-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE8B |
| Gene ID: |
8622 |
| Uniprot ID: |
PDE8B_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PDE8B (NP_003710.1). |
| Immunogen Sequence: |
MGCAPSIHVSQSGVIYCRDS DESSSPRQTTSVSQGPAAPL PGLFVQTDAADAIPPSRASG PPSVARVRRARTELGSGSSA GSAAPAATTSRGRRRHCCSS AEAETQTCYTSVKQVSSAEV RIGPMRLTQDPIQVLLIFAK EDSQSDGFWWACDRAGYRCN IARTPESALECFLDKHHEII VIDHRQTQNFDAEAVCRSIR ATNPSEHTVI |
| Tissue Specificity | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| Protein Name | High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8bHspde8bCell Proliferation-Inducing Gene 22 Protein |
| Database Links | Reactome: R-HSA-418555 |
| Alternative Antibody Names | Anti-High Affinity Camp-Specific And Ibmx-Insensitive 3' -5'-Cyclic Phosphodiesterase 8b antibodyAnti-Hspde8b antibodyAnti-Cell Proliferation-Inducing Gene 22 Protein antibodyAnti-PDE8B antibodyAnti-PIG22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
