| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDCD1LG2 |
| Gene ID: | 80380 |
| Uniprot ID: | PD1L2_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PDCD1LG2 (NP_079515.2). |
| Immunogen Sequence: | YQCIIIYGVAWDYKYLTLKV KASYRKINTHILKVPETDEV ELTCQATGYPLAEVSWPNVS VPANTSHSRTPEGLYQVTSV LRLKPPPGRNFSCVFWNTHV R |
| Tissue Specificity | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Protein Name | Programmed Cell Death 1 Ligand 2 Pd-1 Ligand 2 Pd-L2 Pdcd1 Ligand 2 Programmed Death Ligand 2 Butyrophilin B7-Dc B7-Dc Cd Antigen Cd273 |
| Database Links | Reactome: R-HSA-389948 |
| Cellular Localisation | Isoform 3: Secreted Isoform 2: Endomembrane System Single-Pass Type I Membrane Protein Isoform 1: Cell Membrane |
| Alternative Antibody Names | Anti-Programmed Cell Death 1 Ligand 2 antibody Anti-Pd-1 Ligand 2 antibody Anti-Pd-L2 antibody Anti-Pdcd1 Ligand 2 antibody Anti-Programmed Death Ligand 2 antibody Anti-Butyrophilin B7-Dc antibody Anti-B7-Dc antibody Anti-Cd Antigen Cd273 antibody Anti-PDCD1LG2 antibody Anti-B7DC antibody Anti-CD273 antibody Anti-PDCD1L2 antibody Anti-PDL2 antibody |
Information sourced from Uniprot.org