| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAPSS1 (190-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAPSS1 |
| Gene ID: |
9061 |
| Uniprot ID: |
PAPS1_HUMAN |
| Immunogen Region: |
190-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 190-260 of human PAPSS1 (NP_005434.4). |
| Immunogen Sequence: |
SEYEKPEAPELVLKTDSCDV NDCVQQVVELLQERDIVPVD ASYEVKELYVPENKLHLAKT DAETLPALKIN |
| Tissue Specificity | Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate.APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. |
| Protein Name | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1Paps Synthase 1Papss 1Sulfurylase Kinase 1Sk 1Sk1 Includes - Sulfate AdenylyltransferaseAtp-SulfurylaseSulfate Adenylate TransferaseSat - Adenylyl-Sulfate Kinase3'-Phosphoadenosine-5'-Phosphosulfate SynthaseAps KinaseAdenosine-5'-Phosphosulfate 3'-PhosphotransferaseAdenylylsulfate 3'-Phosphotransferase |
| Database Links | Reactome: R-HSA-174362Reactome: R-HSA-2408550Reactome: R-HSA-6802952 |
| Alternative Antibody Names | Anti-Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 antibodyAnti-Paps Synthase 1 antibodyAnti-Papss 1 antibodyAnti-Sulfurylase Kinase 1 antibodyAnti-Sk 1 antibodyAnti-Sk1 Includes - Sulfate Adenylyltransferase antibodyAnti-Atp-Sulfurylase antibodyAnti-Sulfate Adenylate Transferase antibodyAnti-Sat - Adenylyl-Sulfate Kinase antibodyAnti-3'-Phosphoadenosine-5'-Phosphosulfate Synthase antibodyAnti-Aps Kinase antibodyAnti-Adenosine-5'-Phosphosulfate 3'-Phosphotransferase antibodyAnti-Adenylylsulfate 3'-Phosphotransferase antibodyAnti-PAPSS1 antibodyAnti-ATPSK1 antibodyAnti-PAPSS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
