| Tissue Specificity | Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. |
| Post Translational Modifications | Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility. |
| Function | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. |
| Protein Name | PalladinSih002Sarcoma Antigen Ny-Sar-77 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionMyofibrilSarcomereZ LineCell ProjectionRufflePodosomeLamellipodiumAxonGrowth ConeLocalizes To Stress Fibers And Z LinesPreferentially Expressed In The Excitatory Presynaptic Terminals |
| Alternative Antibody Names | Anti-Palladin antibodyAnti-Sih002 antibodyAnti-Sarcoma Antigen Ny-Sar-77 antibodyAnti-PALLD antibodyAnti-KIAA0992 antibodyAnti-CGI-151 antibody |
Information sourced from Uniprot.org
