| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAFAH2 (260-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAFAH2 |
| Gene ID: |
5051 |
| Uniprot ID: |
PAFA2_HUMAN |
| Immunogen Region: |
260-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 260-350 of human PAFAH2 (NP_000428.2). |
| Immunogen Sequence: |
AWMFPLERDFYPKARGPVFF INTEKFQTMESVNLMKKICA QHEQSRIITVLGSVHRSQTD FAFVTGNLIGKFFSTETRGS LDPYEGQEVMV |
| Tissue Specificity | Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex. |
| Function | Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase 2 - CytoplasmicPaf -Lysophospholipid TransacetylasePaf -Sphingosine TransacetylasePlatelet-Activating Factor Acetyltransferase Pafah2Serine-Dependent Phospholipase A2Sd-Pla2Hsd-Pla2 |
| Database Links | Reactome: R-HSA-418346 |
| Cellular Localisation | CytoplasmMembraneLipid-AnchorEndoplasmic Reticulum MembraneIn Resting CellsLocalizes To Intracellular Membranes And CytoplasmTranslocates From The Cytoplasm To Intracellular Membranes Upon Oxidative Stress |
| Alternative Antibody Names | Anti-Platelet-Activating Factor Acetylhydrolase 2 - Cytoplasmic antibodyAnti-Paf -Lysophospholipid Transacetylase antibodyAnti-Paf -Sphingosine Transacetylase antibodyAnti-Platelet-Activating Factor Acetyltransferase Pafah2 antibodyAnti-Serine-Dependent Phospholipase A2 antibodyAnti-Sd-Pla2 antibodyAnti-Hsd-Pla2 antibodyAnti-PAFAH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
