| Tissue Specificity | In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain. |
| Function | Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1Paf Acetylhydrolase 29 Kda SubunitPaf-Ah 29 Kda SubunitPaf-Ah Subunit GammaPafah Subunit Gamma |
| Database Links | Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Platelet-Activating Factor Acetylhydrolase Ib Subunit Alpha1 antibodyAnti-Paf Acetylhydrolase 29 Kda Subunit antibodyAnti-Paf-Ah 29 Kda Subunit antibodyAnti-Paf-Ah Subunit Gamma antibodyAnti-Pafah Subunit Gamma antibodyAnti-PAFAH1B3 antibodyAnti-PAFAHG antibody |
Information sourced from Uniprot.org
