| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAEP (19-180) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAEP |
| Gene ID: |
5047 |
| Uniprot ID: |
PAEP_HUMAN |
| Immunogen Region: |
19-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 19-180 of human PAEP (NP_002562.2). |
| Immunogen Sequence: |
MDIPQTKQDLELPKLAGTWH SMAMATNNISLMATLKAPLR VHITSLLPTPEDNLEIVLHR WENNSCVEKKVLGEKTENPK KFKINYTVANEATLLDTDYD NFLFLCLQDTTTPIQSMMCQ YLARVLVEDDEIMQGFIRAF RPLPRHLWYLLDLKQMEEPC RF |
| Tissue Specificity | This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling. |
| Post Translational Modifications | Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C. |
| Function | Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa. |
| Protein Name | GlycodelinGdPlacental Protein 14Pp14Pregnancy-Associated Endometrial Alpha-2 GlobulinPaegPegProgestagen-Associated Endometrial ProteinProgesterone-Associated Endometrial ProteinZona-Binding Inhibitory Factor-1Zif-1 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Glycodelin antibodyAnti-Gd antibodyAnti-Placental Protein 14 antibodyAnti-Pp14 antibodyAnti-Pregnancy-Associated Endometrial Alpha-2 Globulin antibodyAnti-Paeg antibodyAnti-Peg antibodyAnti-Progestagen-Associated Endometrial Protein antibodyAnti-Progesterone-Associated Endometrial Protein antibodyAnti-Zona-Binding Inhibitory Factor-1 antibodyAnti-Zif-1 antibodyAnti-PAEP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
