Western blot analysis of lysates from 293T cells, using PACS1 Rabbit polyclonal antibody (STJ114533) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-PACS1 antibody (420-560) (STJ114533)

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STJ114533
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:3000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PACS1
Gene ID: 55690
Uniprot ID: PACS1_HUMAN
Immunogen Region: 420-560
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2).
Immunogen Sequence: SKGSLGKDTTSPMELAALEK IKSTWIKNQDDSLTETDTLE ITDQDMFGDASTSLVVPEKV KTPMKSSKTDLQGSASPSKV EGVHTPRQKRSTPLKERQLS KPLSERTNSSDSERSPDLGH STQIPRKVVYDQLNQILVSD A
Function Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations.
Protein Name Phosphofurin Acidic Cluster Sorting Protein 1
Pacs-1
Database Links Reactome: R-HSA-164940
Cellular Localisation Golgi Apparatus
Trans-Golgi Network
Localizes In The Perinuclear Region
Probably The Tgn
Alternative Antibody Names Anti-Phosphofurin Acidic Cluster Sorting Protein 1 antibody
Anti-Pacs-1 antibody
Anti-PACS1 antibody
Anti-KIAA1175 antibody

Information sourced from Uniprot.org

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