| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PACRG (150-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PACRG |
| Gene ID: |
135138 |
| Uniprot ID: |
PACRG_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1). |
| Immunogen Sequence: |
IIPIKNALNLRNRQVICVTL KVLQHLVVSAEMVGKALVPY YRQILPVLNIFKNMNVNSGD GIDYSQQKRENIGDLIQETL EAFERYGGENAFINIKYVVP T |
| Tissue Specificity | Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients. |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. |
| Protein Name | Parkin Coregulated Gene ProteinMolecular Chaperone/Chaperonin-Binding ProteinPark2 Coregulated Gene Protein |
| Cellular Localisation | CytoplasmCytoskeletonCilium Axoneme |
| Alternative Antibody Names | Anti-Parkin Coregulated Gene Protein antibodyAnti-Molecular Chaperone/Chaperonin-Binding Protein antibodyAnti-Park2 Coregulated Gene Protein antibodyAnti-PACRG antibodyAnti-GLUP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
