Anti-p53 DINP1 antibody (100-200) [S6MR] (STJ11103596)

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STJ11103596
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TP53INP1
Gene ID: 94241
Uniprot ID: T53I1_HUMAN
Immunogen Region: 100-200
Specificity: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p53 DINP1 (Q96A56).
Immunogen Sequence: PPPCFTAGGLTTIKVETSPM ENLLIEHPSMSVYAVHNSCP GLSEATRGTDELHSPSSPRV EAQNEMGQHIHCYVAALAAH TTFLEQPKSFRPSQWIKEHS E
Tissue Specificity Ubiquitously expressed.
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Protein Name Tumor Protein P53-Inducible Nuclear Protein 1
Stress-Induced Protein
P53-Dependent Damage-Inducible Nuclear Protein 1
P53dinp1
Database Links Reactome: R-HSA-6803204
Reactome: R-HSA-6804756
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Pml Body
Cytoplasmic Vesicle
Autophagosome
Shuttles Between The Nucleus And The Cytoplasm
Depending On Cellular Stress Conditions
And Re-Localizes To Autophagosomes On Autophagy Activation
Alternative Antibody Names Anti-Tumor Protein P53-Inducible Nuclear Protein 1 antibody
Anti-Stress-Induced Protein antibody
Anti-P53-Dependent Damage-Inducible Nuclear Protein 1 antibody
Anti-P53dinp1 antibody
Anti-TP53INP1 antibody
Anti-P53DINP1 antibody
Anti-SIP antibody

Information sourced from Uniprot.org