• Invasive cervical squamous cell carcinoma stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of carcinoma cells.

Anti-P16INK4a antibody (1-156aa) [MX007] (STJ180271)

SKU:
STJ180271

Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Mouse monoclonal antibody anti-P16INK4a (1-156aa) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MX007
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Buffer with protein carrier and preservative
Purification: Affinity purified
Dilution Range: 1:100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: CDKN2A
Gene ID: 1029
Uniprot ID: CDN2A_HUMAN
Immunogen Region: 1-156aa
Specificity: Positive control: Cervical squamous cell carcinoma
Immunogen: Recombinant human p16INK4a protein (aa1-156)
Tissue Specificity Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Post Translational Modifications Phosphorylation seems to increase interaction with CDK4.
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Protein Name Cyclin-Dependent Kinase Inhibitor 2a
Cyclin-Dependent Kinase 4 Inhibitor A
Cdk4i
Multiple Tumor Suppressor 1
Mts-1
P16-Ink4a
P16-Ink4
P16ink4a
Database Links Reactome: R-HSA-111471
Reactome: R-HSA-2559580
Reactome: R-HSA-2559585
Reactome: R-HSA-3108214
Reactome: R-HSA-3232118
Reactome: R-HSA-6804757
Reactome: R-HSA-69541
Reactome: R-HSA-8941858
Reactome: R-HSA-9645722
Reactome: R-HSA-9646303
Reactome: R-HSA-9646304
Reactome: R-HSA-2559582
Reactome: R-HSA-69231
Reactome: R-HSA-8853884
Reactome: R-HSA-9630791
Reactome: R-HSA-9630794
Reactome: R-HSA-9632697
Reactome: R-HSA-9632700
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cyclin-Dependent Kinase Inhibitor 2a antibody
Anti-Cyclin-Dependent Kinase 4 Inhibitor A antibody
Anti-Cdk4i antibody
Anti-Multiple Tumor Suppressor 1 antibody
Anti-Mts-1 antibody
Anti-P16-Ink4a antibody
Anti-P16-Ink4 antibody
Anti-P16ink4a antibody
Anti-CDKN2A antibody
Anti-CDKN2 antibody
Anti-MTS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance