Western blot analysis of extracts of various cell lines, using OSGEP antibody (STJ29609) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-OSGEP antibody (1-335) (STJ29609)

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STJ29609
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OSGEP
Gene ID: 55644
Uniprot ID: OSGEP_HUMAN
Immunogen Region: 1-335
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human OSGEP (NP_060277.1).
Immunogen Sequence: MPAVLGFEGSANKIGVGVVR DGKVLANPRRTYVTPPGTGF LPGDTARHHRAVILDLLQEA LTESGLTSQDIDCIAYTKGP GMGAPLVSVAVVARTVAQLW NKPLVGVNHCIGHIEMGRLI TGATSPTVLYVSGGNTQVIA YSEHRYRIFGETIDIAVGNC LDRFARVLKISNDPSPGYNI EQMAKRGKKLVELPYTVKGM DVSFSGILSFIEDVAHRMLA TGECTPEDLCFSLQETVFA
Tissue Specificity Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Protein Name Trna N6-Adenosine Threonylcarbamoyltransferase
N6-L-Threonylcarbamoyladenine Synthase
T(6a Synthase
O-Sialoglycoprotein Endopeptidase
Hosgep
T(6a37 Threonylcarbamoyladenosine Biosynthesis Protein Osgep
Trna Threonylcarbamoyladenosine Biosynthesis Protein Osgep
Database Links Reactome: R-HSA-6782315
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Trna N6-Adenosine Threonylcarbamoyltransferase antibody
Anti-N6-L-Threonylcarbamoyladenine Synthase antibody
Anti-T(6a Synthase antibody
Anti-O-Sialoglycoprotein Endopeptidase antibody
Anti-Hosgep antibody
Anti-T(6a37 Threonylcarbamoyladenosine Biosynthesis Protein Osgep antibody
Anti-Trna Threonylcarbamoyladenosine Biosynthesis Protein Osgep antibody
Anti-OSGEP antibody
Anti-GCPL1 antibody

Information sourced from Uniprot.org

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