| Tissue Specificity | Detected in blood leukocytes. |
| Post Translational Modifications | Phosphorylation at Ser-363 requires GRK3. |
| Function | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. |
| Protein Name | Nociceptin ReceptorKappa-Type 3 Opioid ReceptorKor-3Orphanin Fq Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleLigand Binding Leads To Receptor Internalization Into Cytoplasmic VesiclesDecreasing The Amount Of Available Receptor At The Cell SurfaceInternalization Requires Phosphorylation At Ser-363Can Recycle To The Cell Membrane |
| Alternative Antibody Names | Anti-Nociceptin Receptor antibodyAnti-Kappa-Type 3 Opioid Receptor antibodyAnti-Kor-3 antibodyAnti-Orphanin Fq Receptor antibodyAnti-OPRL1 antibodyAnti-OOR antibodyAnti-ORL1 antibody |
Information sourced from Uniprot.org
