| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OPRD1 |
| Gene ID: | 4985 |
| Uniprot ID: | OPRD_HUMAN |
| Immunogen Region: | 283-372 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 283-372 of human OPRD1 (NP_000902.3). |
| Immunogen Sequence: | VWTLVDIDRRDPLVVAALHL CIALGYANSSLNPVLYAFLD ENFKRCFRQLCRKPCGRPDP SSFSRAREATARERVTACTP SDGPGGGAAA |
| Tissue Specificity | Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. |
| Post Translational Modifications | N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation.the ubiquitination is diminished by RTP4. |
| Function | G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
| Protein Name | Delta-Type Opioid Receptor D-Or-1 Dor-1 |
| Database Links | Reactome: R-HSA-375276 Reactome: R-HSA-418594 Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Delta-Type Opioid Receptor antibody Anti-D-Or-1 antibody Anti-Dor-1 antibody Anti-OPRD1 antibody Anti-OPRD antibody |
Information sourced from Uniprot.org