| Tissue Specificity | Expressed in testis, thymus, brain, and heart, and at lower levels in ovaries and spleen. |
| Post Translational Modifications | Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1. |
| Function | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration. Plays a role in the vascular response to injury. In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. |
| Protein Name | Nuclear Receptor Subfamily 4 Group A Member 1Nuclear Hormone Receptor Nur/77Nuclear Protein N10Orphan Nuclear Receptor Hmr |
| Database Links | Reactome: R-MMU-198693Reactome: -MMU-383280 |
| Cellular Localisation | NucleusCytoplasmCytosolMitochondrionNuclear Export To The Cytosol Is Xpo1-Mediated And Positively Regulated By Ifi27Translocation To The Mitochondrion Upon Interaction With Rxra And Upon The Presence Of 9-Cis Retinoic Acid |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 4 Group A Member 1 antibodyAnti-Nuclear Hormone Receptor Nur/77 antibodyAnti-Nuclear Protein N10 antibodyAnti-Orphan Nuclear Receptor Hmr antibodyAnti-Nr4a1 antibodyAnti-Gfrp antibodyAnti-Hmr antibodyAnti-N10 antibodyAnti-Nur77 antibody |
Information sourced from Uniprot.org
