| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUBP2 |
| Gene ID: | 10101 |
| Uniprot ID: | NUBP2_HUMAN |
| Immunogen Region: | 142-271 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 142-271 of human NUBP2 (NP_036357.1). |
| Immunogen Sequence: | MATIEALRPYQPLGALVVTT PQAVSVGDVRRELTFCRKTG LRVMGIVENMSGFTCPHCTE CTSVFSRGGGEELAQLAGVP FLGSVPLDPALMRTLEEGHD FIQEFPGSPAFAALTSIAQK ILDATPACLP |
| Tissue Specificity | Widely expressed with highest expression in skeletal muscle. |
| Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. |
| Protein Name | Cytosolic Fe-S Cluster Assembly Factor Nubp2 Nucleotide-Binding Protein 2 Nbp 2 |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Cilium Axoneme Centriole Enriched At The Centrosomes During Mitosis Enriched In Centrioles Of Microtubule Asters During Prophase Prometaphase And Telophase Stages Of Mitosis Localized At Centrioles And In The Nucleus At Interphase Colocalizes With Nubp-1 At Prometaphase |
| Alternative Antibody Names | Anti-Cytosolic Fe-S Cluster Assembly Factor Nubp2 antibody Anti-Nucleotide-Binding Protein 2 antibody Anti-Nbp 2 antibody Anti-NUBP2 antibody |
Information sourced from Uniprot.org