| Function | Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage. |
| Protein Name | Neuronal Vesicle Trafficking-Associated Protein 1Neuron-Enriched Endosomal Protein Of 21 KdaNeuron-Specific Protein Family Member 1 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneCell ProjectionDendriteEarly Endosome MembraneLate Endosome MembraneLysosome LumenRecycling Endosome MembraneCytoplasmic Vesicle MembraneGolgi Stack MembraneEndosomeMultivesicular Body MembraneEndoplasmic Reticulum MembraneEndocytosed From The Cell SurfaceThus Enters Into Early EndosomesTrafficks To Late Endosomes And Degradates In LysosomesEndoplasmic Reticulum Targeting Is Essential For ApoptosisFound In Both Stationary And Motile EndosomesA Previous Study Supports A Type I Membrane Protein Topology |
| Alternative Antibody Names | Anti-Neuronal Vesicle Trafficking-Associated Protein 1 antibodyAnti-Neuron-Enriched Endosomal Protein Of 21 Kda antibodyAnti-Neuron-Specific Protein Family Member 1 antibodyAnti-NSG1 antibodyAnti-D4S234 antibodyAnti-NEEP21 antibody |
Information sourced from Uniprot.org
