| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRBP1 (406-535) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRBP1 |
| Gene ID: |
29959 |
| Uniprot ID: |
NRBP_HUMAN |
| Immunogen Region: |
406-535 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 406-535 of human NRBP1 (NP_037524.1). |
| Immunogen Sequence: |
AFGLPRPQQPQQEEVTSPVV PPSVKTPTPEPAEVETRKVV LMQCNIESVEEGVKHHLTLL LKLEDKLNRHLSCDLMPNEN IPELAAELVQLGFISEADQS RLTSLLEETLNKFNFARNST LNSAAVTVSS |
| Tissue Specificity | Ubiquitously expressed in all tissues examined with high levels in the testis. |
| Function | Required for embryonic development. Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes. May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. |
| Protein Name | Nuclear Receptor-Binding Protein |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | CytoplasmCell CortexEndomembrane SystemCell ProjectionLamellipodiumColocalizes With Activated Rac3 To Endomembranes And At The Cell Periphery In Lamellipodia |
| Alternative Antibody Names | Anti-Nuclear Receptor-Binding Protein antibodyAnti-NRBP1 antibodyAnti-BCON3 antibodyAnti-NRBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
