| Tissue Specificity | Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma. |
| Function | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation. |
| Protein Name | Nuclear Receptor-Binding Factor 2Nrbf-2Comodulator Of Ppar And Rxr |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Nuclear Receptor-Binding Factor 2 antibodyAnti-Nrbf-2 antibodyAnti-Comodulator Of Ppar And Rxr antibodyAnti-NRBF2 antibodyAnti-COPR antibody |
Information sourced from Uniprot.org
![Immunohistochemistry analysis of paraffin-embedded human esophageal using [KO Validated] NRBF2 rabbit polyclonal antibody (STJ28545) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101825/390024/STJ28545_IHC_3__15750.1713159905.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human esophageal using [KO Validated] NRBF2 rabbit polyclonal antibody (STJ28545) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9. 0 before commencing with immunohistochemistry staining protocol.")
