• Western blot analysis of various lysates using NPSR1 Rabbit polyclonal antibody (STJ119046) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 10s.

Anti-NPSR1 antibody (C-Term) (STJ119046)

SKU:
STJ119046

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NPSR1 (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NPSR1
Gene ID: 387129
Uniprot ID: NPSR1_HUMAN
Immunogen Region: C-Term
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human NPSR1 (NP_001287863.1).
Immunogen Sequence: SKAKIKAIKYSIIIILAFIC CWSPYFLFDILDNFNLLPDT QERFYASVIIQNLPALNSAI NPLIYCVFSSSISFPCREQR SQDSRMTFRERTERHEMQIL SKPEFI
Tissue Specificity Isoform 4 is ubiquitous.it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients.whereas in epithelial cells, its expression is consistently stronger in asthma patients.
Function G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
Protein Name Neuropeptide S Receptor
G-Protein Coupled Receptor 154
G-Protein Coupled Receptor Pgr14
G-Protein Coupled Receptor For Asthma Susceptibility
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-418555
Cellular Localisation Isoform 1: Cell Membrane
Multi-Pass Membrane Protein
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Isoform 2: Cytoplasm
Isoform 5: Cytoplasm
Isoform 6: Cytoplasm
Isoform 7: Cytoplasm
Isoform 9: Cytoplasm
Alternative Antibody Names Anti-Neuropeptide S Receptor antibody
Anti-G-Protein Coupled Receptor 154 antibody
Anti-G-Protein Coupled Receptor Pgr14 antibody
Anti-G-Protein Coupled Receptor For Asthma Susceptibility antibody
Anti-NPSR1 antibody
Anti-GPR154 antibody
Anti-GPRA antibody
Anti-PGR14 antibody

Information sourced from Uniprot.org

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