| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEURL1B |
| Gene ID: | 54492 |
| Uniprot ID: | NEU1B_HUMAN |
| Immunogen Region: | 270-440 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-440 of human NEURL1B (NP_001136123.1). |
| Immunogen Sequence: | ASSPALLEADLRFHATRGPD VSLSADRKVACAPRPDGGRT LVFSERPLRPGESLFVEVGR PGLAAPGALAFGITSCDPGV LRPNELPADPDALLDRKEYW VVARAGPVPSGGDALSFTLR PGGDVLLGINGRPRGRLLCV DTTQALWAFFAVRGGVAGQL RLLGTLQSSPA |
| Tissue Specificity | Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe. |
| Function | E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. |
| Protein Name | E3 Ubiquitin-Protein Ligase Neurl1bNeuralized-2Neur2Neuralized-Like Protein 1bNeuralized-Like Protein 3Ring-Type E3 Ubiquitin Transferase Neurl1b |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Neurl1b antibodyAnti-Neuralized-2 antibodyAnti-Neur2 antibodyAnti-Neuralized-Like Protein 1b antibodyAnti-Neuralized-Like Protein 3 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Neurl1b antibodyAnti-NEURL1B antibodyAnti-NEURL3 antibody |
Information sourced from Uniprot.org