• Western blot analysis of lysates from MCF-7 cells, using NEURL1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-NEURL1 antibody (219-268) (STJ94417)

SKU:
STJ94417

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase NEURL1 (219-268) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NEURL1
Gene ID: 9148
Uniprot ID: NEUL1_HUMAN
Immunogen Region: 219-268
Specificity: Neuralized-1 Polyclonal Antibody detects endogenous levels of Neuralized-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NEURL1. AA range:219-268
Tissue Specificity Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
Post Translational Modifications Myristoylation is a determinant of membrane targeting.
Function Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor.inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Protein Name E3 Ubiquitin-Protein Ligase Neurl1
Neuralized-Like Protein 1a
H-Neu
H-Neuralized 1
Ring Finger Protein 67
Ring-Type E3 Ubiquitin Transferase Neurl1
Database Links Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2691232
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-9013507
Cellular Localisation Cytoplasm
Perinuclear Region
Cell Membrane
Peripheral Membrane Protein
Perikaryon
Cell Projection
Dendrite
Postsynaptic Density
Localized In The Cell Bodies Of The Pyramidal Neurons And Distributed Along Their Apical Dendrites
Colocalized With Psd95 In Postsynaptic Sites
Colocalized With Cpeb3 At Apical Dendrites Of Ca1 Neurons
Colocalized With Jag1 At The Cell Surface
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Neurl1 antibody
Anti-Neuralized-Like Protein 1a antibody
Anti-H-Neu antibody
Anti-H-Neuralized 1 antibody
Anti-Ring Finger Protein 67 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Neurl1 antibody
Anti-NEURL1 antibody
Anti-NEURL antibody
Anti-NEURL1A antibody
Anti-RNF67 antibody

Information sourced from Uniprot.org

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