| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEK4 |
| Gene ID: | 6787 |
| Uniprot ID: | NEK4_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NEK4 (NP_003148.2). |
| Immunogen Sequence: | MPLAAYCYLRVVGKGSYGEV TLVKHRRDGKQYVIKKLNLR NASSRERRAAEQEAQLLSQL KHPNIVTYKESWEGGDGLLY IVMGFCEGGDLYRKLKEQKG QLLPENQVVEWFVQIAMALQ YLHEKHILHRDLKTQNVFLT RTNIIKVGDLGIARVLENHC DMASTLIGTPYYMSPELFSN KPYNYKSDVWALGCCVYEMA TLKHAFNAKDMNSLVYRIIE GKLPPMPRDYSPELAELIR |
| Tissue Specificity | Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. |
| Function | Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. |
| Protein Name | Serine/Threonine-Protein Kinase Nek4Never In Mitosis A-Related Kinase 4Nima-Related Protein Kinase 4Serine/Threonine-Protein Kinase 2Serine/Threonine-Protein Kinase Nrk2 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek4 antibodyAnti-Never In Mitosis A-Related Kinase 4 antibodyAnti-Nima-Related Protein Kinase 4 antibodyAnti-Serine/Threonine-Protein Kinase 2 antibodyAnti-Serine/Threonine-Protein Kinase Nrk2 antibodyAnti-NEK4 antibodyAnti-STK2 antibody |
Information sourced from Uniprot.org