| Function | Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. |
| Protein Name | N-Acetyltransferase 8Acetyltransferase 2Atase2Camello-Like Protein 1Cysteinyl-Conjugate N-AcetyltransferaseCcnat |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-N-Acetyltransferase 8 antibodyAnti-Acetyltransferase 2 antibodyAnti-Atase2 antibodyAnti-Camello-Like Protein 1 antibodyAnti-Cysteinyl-Conjugate N-Acetyltransferase antibodyAnti-Ccnat antibodyAnti-NAT8 antibodyAnti-CML1 antibodyAnti-GLA antibodyAnti-TSC501 antibody |
Information sourced from Uniprot.org
