Anti-MUC4 antibody [ABT174R] (STJ197078)

SKU:
STJ197078

Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mucin-4 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Clone ID: ABT174R
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:50
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MUC4
Gene ID: 4585
Uniprot ID: MUC4_HUMAN
Specificity: This antibody detects endogenous levels of MUC4 at Human
Immunogen: Synthesized peptide derived from the human MUC4
Post Translational Modifications Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. Mucin-4 alpha chain: Highly O-glycosylated. Mucin-4 beta chain: Is predominantly N-glycosylated.
Function Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
Protein Name Mucin-4
Muc-4
Ascites Sialoglycoprotein
Asgp
Pancreatic Adenocarcinoma Mucin
Testis Mucin
Tracheobronchial Mucin Cleaved Into - Mucin-4 Alpha Chain
Ascites Sialoglycoprotein 1
Asgp-1 - Mucin-4 Beta Chain
Ascites Sialoglycoprotein 2
Asgp-2
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Mucin-4 Beta Chain: Cell Membrane
Single-Pass Membrane Protein
Isoforms Lacking The Cys-Rich Region
Egf-Like Domains And Transmembrane Region Are Secreted
Secretion Occurs By Splicing Or Proteolytic Processing
Mucin-4 Alpha Chain: Cell Membrane
Secreted
Forms A Complex With Mucin-4 Beta Chain At The Cell Membrane
Isoform 3: Cell Membrane
Isoform 11: Secreted
Isoform 15: Secreted
Isoform 17: Cell Membrane
Alternative Antibody Names Anti-Mucin-4 antibody
Anti-Muc-4 antibody
Anti-Ascites Sialoglycoprotein antibody
Anti-Asgp antibody
Anti-Pancreatic Adenocarcinoma Mucin antibody
Anti-Testis Mucin antibody
Anti-Tracheobronchial Mucin Cleaved Into - Mucin-4 Alpha Chain antibody
Anti-Ascites Sialoglycoprotein 1 antibody
Anti-Asgp-1 - Mucin-4 Beta Chain antibody
Anti-Ascites Sialoglycoprotein 2 antibody
Anti-Asgp-2 antibody
Anti-MUC4 antibody

Information sourced from Uniprot.org

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