| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MSX2 (1-267) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MSX2 |
| Gene ID: |
4488 |
| Uniprot ID: |
MSX2_HUMAN |
| Immunogen Region: |
1-267 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-267 of human MSX2 (NP_002440.2). |
| Immunogen Sequence: |
MASPSKGNDLFSPDEEGPAV VAGPGPGPGGAEGAAEERRV KVSSLPFSVEALMSDKKPPK EASPLPAESASAGATLRPLL LSGHGAREAHSPGPLVKPFE TASVKSENSEDGAAWMQEPG RYSPPPRHMSPTTCTLRKHK TNRKPRTPFTTSQLLALERK FRQKQYLSIAERAEFSSSLN LTETQVKIWFQNRRAKAKRL QEAELEKLKMAAKPMLPSSF SLPFPISSPLQAASIYGAS |
| Function | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. |
| Protein Name | Homeobox Protein Msx-2Homeobox Protein Hox-8 |
| Database Links | Reactome: R-HSA-8939902 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Msx-2 antibodyAnti-Homeobox Protein Hox-8 antibodyAnti-MSX2 antibodyAnti-HOX8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
