| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MSL2 (328-577) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MSL2 |
| Gene ID: |
55167 |
| Uniprot ID: |
MSL2_HUMAN |
| Immunogen Region: |
328-577 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 328-577 of human MSL2 (NP_060603.2). |
| Immunogen Sequence: |
CTAATPKIAKLNRKRSRSES DSEKVQPLPISTIIRGPTLG ASAPVTVKRESKISLQPIAT VPNGGTTPKISKTVLLSTKS MKKSHEHGSKKSHSKTKPGI LKKDKAVKEKIPSHHFMPGS PTKTVYKKPQEKKGCKCGRA TQNPSVLTCRGQRCPCYSNR KACLDCICRGCQNSYMANGE KKLEAFAVPEKALEQTRLTL GINVTSIAVRNASTSTSVIN VTGSPVTTFLAASTHDDKS |
| Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Msl2E3 Ubiquitin-Protein Transferase Msl2Male-Specific Lethal 2-Like 1Msl2-Like 1Male-Specific Lethal-2 HomologMsl-2Male-Specific Lethal-2 Homolog 1Ring Finger Protein 184 |
| Database Links | Reactome: R-HSA-3214847 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Msl2 antibodyAnti-E3 Ubiquitin-Protein Transferase Msl2 antibodyAnti-Male-Specific Lethal 2-Like 1 antibodyAnti-Msl2-Like 1 antibodyAnti-Male-Specific Lethal-2 Homolog antibodyAnti-Msl-2 antibodyAnti-Male-Specific Lethal-2 Homolog 1 antibodyAnti-Ring Finger Protein 184 antibodyAnti-MSL2 antibodyAnti-KIAA1585 antibodyAnti-MSL2L1 antibodyAnti-RNF184 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
