• Immunofluorescence analysis of paraffin-embedded mouse bone marrow using TPO-R/CD110/c-TPO-R/CD110/c-Mpl Rabbit polyclonal antibody (STJ119126) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded human spleen using TPO-R/CD110/c-TPO-R/CD110/c-Mpl Rabbit polyclonal antibody (STJ119126) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded rat bone marrow using TPO-R/CD110/c-TPO-R/CD110/c-Mpl Rabbit polyclonal antibody (STJ119126) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Western blot analysis of lysates from Mouse heart, using TPO-R/CD110/c-Mpl Rabbit polyclonal antibody (STJ119126) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-MPL antibody (295-390) (STJ119126)

SKU:
STJ119126

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MPL (295-390) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MPL
Gene ID: 4352
Uniprot ID: TPOR_HUMAN
Immunogen Region: 295-390
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 295-390 of human TPO-R/CD110/c-Mpl (NP_005364.1).
Immunogen Sequence: DLKNVTCQWQQQDHASSQGF FYHSRARCCPRDRYPIWENC EEEEKTNPGLQTPQFSRCHF KSRNDSIIHILVEVTTAPGT VHSYLGSPFWIHQAVR
Tissue Specificity Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Post Translational Modifications Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
Function Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Protein Name Thrombopoietin Receptor
Tpo-R
Myeloproliferative Leukemia Protein
Proto-Oncogene C-Mpl
Cd Antigen Cd110
Database Links Reactome: R-HSA-76009
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cell Surface
Alternative Antibody Names Anti-Thrombopoietin Receptor antibody
Anti-Tpo-R antibody
Anti-Myeloproliferative Leukemia Protein antibody
Anti-Proto-Oncogene C-Mpl antibody
Anti-Cd Antigen Cd110 antibody
Anti-MPL antibody
Anti-TPOR antibody

Information sourced from Uniprot.org

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