| Tissue Specificity | Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney. |
| Post Translational Modifications | Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. |
| Function | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. (Microbial infection) May be required for influenza A transcription during viral infection. |
| Protein Name | Morc Family Cw-Type Zinc Finger Protein 3Nuclear Matrix Protein 2Zinc Finger Cw-Type Coiled-Coil Domain Protein 3 |
| Cellular Localisation | NucleusNucleoplasmNucleus MatrixPml BodyChromosomeAlso Found In Pml-Independent Nuclear BodiesLocalization To Nuclear Bodies Is Atp-Dependent |
| Alternative Antibody Names | Anti-Morc Family Cw-Type Zinc Finger Protein 3 antibodyAnti-Nuclear Matrix Protein 2 antibodyAnti-Zinc Finger Cw-Type Coiled-Coil Domain Protein 3 antibodyAnti-MORC3 antibodyAnti-KIAA0136 antibodyAnti-NXP2 antibodyAnti-ZCWCC3 antibody |
Information sourced from Uniprot.org
