| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MOAP1 |
| Gene ID: | 64112 |
| Uniprot ID: | MOAP1_HUMAN |
| Immunogen Region: | 1-351 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MOAP1 (NP_071434.2). |
| Immunogen Sequence: | MTLRLLEDWCRGMDMNPRKA LLIAGISQSCSVAEIEEALQ AGLAPLGEYRLLGRMFRRDE NRKVALVGLTAETSHALVPK EIPGKGGIWRVIFKPPDPDN TFLSRLNEFLAGEGMTVGEL SRALGHENGSLDPEQGMIPE MWAPMLAQALEALQPALQCL KYKKLRVFSGRESPEPGEEE FGRWMFHTTQMIKAWQVPDV EKRRRLLESLRGPALDVIRV LKINNPLITVDECLQALEE |
| Tissue Specificity | Widely expressed, with high levels in heart and brain. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. |
| Function | Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex. |
| Protein Name | Modulator Of Apoptosis 1 Map-1 Map1 Paraneoplastic Antigen Ma4 |
| Cellular Localisation | Cytoplasm Cytosol Mitochondrion Outer Membrane Extracellular Vesicle Membrane Forms Virion-Like Extracellular Vesicles That Are Released From Cells |
| Alternative Antibody Names | Anti-Modulator Of Apoptosis 1 antibody Anti-Map-1 antibody Anti-Map1 antibody Anti-Paraneoplastic Antigen Ma4 antibody Anti-MOAP1 antibody Anti-PNMA4 antibody |
Information sourced from Uniprot.org