| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-MIXL1 (185-232 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | MIXL1 |
| Gene ID: | 83881 |
| Uniprot ID: | MIXL1_HUMAN |
| Immunogen Region: | 185-232 aa |
| Specificity: | Specific for MIXL1. |
| Immunogen: | A synthetic peptide from aa region 185-232 of human MIXL1 conjugated to blue carrier protein was used as the antigen. The peptide shares 94% identity with mouse sequence. |
| Post Translational Modifications | Phosphorylated at multiple sites. |
| Function | Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. |
| Protein Name | Homeobox Protein Mixl1Homeodomain Protein MixHmixMix1 Homeobox-Like Protein 1Mix.1 Homeobox-Like Protein |
| Database Links | Reactome: R-HSA-9754189Reactome: R-HSA-9823730 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Mixl1 antibodyAnti-Homeodomain Protein Mix antibodyAnti-Hmix antibodyAnti-Mix1 Homeobox-Like Protein 1 antibodyAnti-Mix.1 Homeobox-Like Protein antibodyAnti-MIXL1 antibodyAnti-MIXL antibody |
Information sourced from Uniprot.org