| Tissue Specificity | Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow. Abundantly expressed in human umbilical vein endothelial cells (at protein level). |
| Function | Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells. |
| Protein Name | Microsomal Glutathione S-Transferase 2Microsomal Gst-2Glutathione Peroxidase Mgst2Leukotriene C4 Synthase Mgst2Microsomal Glutathione S-Transferase IiMicrosomal Gst-Ii |
| Database Links | Reactome: R-HSA-156590Reactome: R-HSA-5423646 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Microsomal Glutathione S-Transferase 2 antibodyAnti-Microsomal Gst-2 antibodyAnti-Glutathione Peroxidase Mgst2 antibodyAnti-Leukotriene C4 Synthase Mgst2 antibodyAnti-Microsomal Glutathione S-Transferase Ii antibodyAnti-Microsomal Gst-Ii antibodyAnti-MGST2 antibodyAnti-GST2 antibody |
Information sourced from Uniprot.org
