| Post Translational Modifications | Autoubiquitinated in vitro. |
| Function | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mgrn1Mahogunin Ring Finger Protein 1Ring Finger Protein 156Ring-Type E3 Ubiquitin Transferase Mgrn1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Early EndosomeThe Endosomal Localization Is Dependent On The Interaction With Tsg101Isoform 1: CytoplasmCytosolNucleusTranslocation From The Cytosol To The Nucleus Is Seen Only In The Presence Of Mc1r And Mc4rBut Not Tbxa2rExcluded From NucleoliIsoform 2: CytoplasmIsoform 3: CytoplasmCell MembraneIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mgrn1 antibodyAnti-Mahogunin Ring Finger Protein 1 antibodyAnti-Ring Finger Protein 156 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mgrn1 antibodyAnti-MGRN1 antibodyAnti-KIAA0544 antibodyAnti-RNF156 antibody |
Information sourced from Uniprot.org
