| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-METTL13 (430-699) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
METTL13 |
| Gene ID: |
51603 |
| Uniprot ID: |
EFNMT_HUMAN |
| Immunogen Region: |
430-699 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 430-699 of human METTL13 (NP_057019.3). |
| Immunogen Sequence: |
LKDVSHKAQKKRKKDRKKQR PADAEDLPAAPGQSIDKSYL CCEHHKAMIAGLALLRNPEL LLEIPLALLVVGLGGGSLPL FVHDHFPKSCIDAVEIDPSM LEVATQWFGFSQSDRMKVHI ADGLDYIASLAGGGEARPCY DVIMFDVDSKDPTLGMSCPP PAFVEQSFLQKVKSILTPEG VFILNLVCRDLGLKDSVLAG LKAVFPLLYVRRIEGEVNEI LFCQLHPEQKLATPELLET |
| Function | Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6. |
| Protein Name | Eef1a Lysine And N-Terminal MethyltransferaseEef1a-KnmtMethyltransferase-Like Protein 13 Includes - Eef1a Lysine Methyltransferase - Eef1a N-Terminal Methyltransferase |
| Cellular Localisation | CytoplasmNucleusMitochondrion |
| Alternative Antibody Names | Anti-Eef1a Lysine And N-Terminal Methyltransferase antibodyAnti-Eef1a-Knmt antibodyAnti-Methyltransferase-Like Protein 13 Includes - Eef1a Lysine Methyltransferase - Eef1a N-Terminal Methyltransferase antibodyAnti-METTL13 antibodyAnti-EEF1AKNMT antibodyAnti-FEAT antibodyAnti-KIAA0859 antibodyAnti-CGI-01 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
