| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | RPL3 |
| Gene ID: | 6122 |
| Uniprot ID: | RL3_HUMAN |
| Specificity: | A synthetic methylated peptide around H245 of human RPL3 (NP_000958.1). |
| Immunogen Sequence: | KTHRG |
| Post Translational Modifications | Constitutively monomethylated at His-245 by METTL18. Methylation at His-245 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. It is not required for incorporation of RPL3 into ribosomes. |
| Function | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. |
| Protein Name | Large Ribosomal Subunit Protein Ul3 60s Ribosomal Protein L3 Hiv-1 Tar Rna-Binding Protein B Tarbp-B |
| Database Links | Reactome: R-HSA-156827 Reactome: R-HSA-156902 Reactome: R-HSA-1799339 Reactome: R-HSA-192823 Reactome: R-HSA-2408557 Reactome: R-HSA-6791226 Reactome: R-HSA-72689 Reactome: R-HSA-72706 Reactome: R-HSA-72764 Reactome: R-HSA-9010553 Reactome: R-HSA-9633012 Reactome: R-HSA-975956 Reactome: R-HSA-975957 |
| Cellular Localisation | Nucleus Nucleolus Cytoplasm |
| Alternative Antibody Names | Anti-Large Ribosomal Subunit Protein Ul3 antibody Anti-60s Ribosomal Protein L3 antibody Anti-Hiv-1 Tar Rna-Binding Protein B antibody Anti-Tarbp-B antibody Anti-RPL3 antibody Anti-OK antibody Anti-SW-cl.32 antibody |
Information sourced from Uniprot.org