| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MED28 (1-178) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MED28 |
| Gene ID: |
80306 |
| Uniprot ID: |
MED28_HUMAN |
| Immunogen Region: |
1-178 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human MED28 (NP_079481.2). |
| Immunogen Sequence: |
MAAPLGGMFSGQPPGPPQAP PGLPGQASLLQAAPGAPRPS SSTLVDELESSFEACFASLV SQDYVNGTDQEEIRTGVDQC IQKFLDIARQTECFFLQKRL QLSVQKPEQVIKEDVSELRN ELQRKDALVQKHLTKLRHWQ QVLEDINVQHKKPADIPQGS LAYLEQASANIPAPLKPT |
| Tissue Specificity | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 28Endothelial-Derived Protein 1Mediator Complex Subunit 28Merlin And Grb2-Interacting Cytoskeletal ProteinMagicinTumor Angiogenesis Marker Eg-1 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381340 |
| Cellular Localisation | NucleusCytoplasmMembranePeripheral Membrane ProteinIt Is Cytoplasmic And Mainly Membrane-Associated |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 28 antibodyAnti-Endothelial-Derived Protein 1 antibodyAnti-Mediator Complex Subunit 28 antibodyAnti-Merlin And Grb2-Interacting Cytoskeletal Protein antibodyAnti-Magicin antibodyAnti-Tumor Angiogenesis Marker Eg-1 antibodyAnti-MED28 antibodyAnti-EG1 antibodyAnti-FKSG20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
