| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCC |
| Gene ID: | 4163 |
| Uniprot ID: | CRCM_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MCC (NP_002378.1). |
| Immunogen Sequence: | MNSGVAMKYGNDSSAELSEL HSAALASLKGDIVELNKRLQ QTERERDLLEKKLAKAQCEQ SHLMREHEDVQERTTLRYEE RITELHSVIAELNKKIDRLQ GTTIREEDEYSELRSELSQS QHEVNEDSRSMDQDQTSVSI PENQSTMVTADMDNCSDLNS ELQRVLTGLENVVCGRKKSS CSLSVAEVDRHIEQLTTASE HCDLAIKTVEEIEGVLGRDL YPNLAEERSRWEKELAGLR |
| Tissue Specificity | Expressed in a variety of tissues. |
| Function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity. |
| Protein Name | Colorectal Mutant Cancer ProteinProtein Mcc |
| Cellular Localisation | Cell MembraneCell ProjectionLamellipodiumNucleusCytoplasmColocalizes With Actin At The Leading Edge Of Polarized Cells |
| Alternative Antibody Names | Anti-Colorectal Mutant Cancer Protein antibodyAnti-Protein Mcc antibodyAnti-MCC antibody |
Information sourced from Uniprot.org