Anti-MBP antibody (STJA0003695)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenThree peptide sequences conserved in higher vertebrate MBP proteins.
General Information
| Short Description | Chicken polyclonal anti-MBP for use in WB, IHC and ICC in Bovine, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Chicken |
| Reactivity | Bovine/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | This antibody was total igy fraction. |
| Dilution Range | WB 1:5000IHC 1:500-1:5000ICC 1:500-1:2000 |
| Formulation | Total IgY fraction in PBS + 10 mM Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Mbp |
| Gene ID | 24547 |
| Uniprot ID | MBP_RAT |
| Immunogen | Three peptide sequences conserved in higher vertebrate MBP proteins. |
Additional Info
| Tissue Specificity | Found in both the central and the peripheral nervous system. |
| Post Translational Modifications | As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. |
| Function | Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane. |
| Protein Name | Myelin Basic ProteinMbp |
| Database Links | |
| Cellular Localisation | Myelin MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic Side Of Myelin |
| Alternative Antibody Names | Anti-Myelin Basic Protein antibodyAnti-Mbp antibodyAnti-Mbp antibody |
Information sourced from Uniprot.org