| Tissue Specificity | Found in both the central and the peripheral nervous system. |
| Post Translational Modifications | As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. |
| Function | Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane. |
| Protein Name | Myelin Basic ProteinMbp |
| Cellular Localisation | Myelin MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic Side Of Myelin |
| Alternative Antibody Names | Anti-Myelin Basic Protein antibodyAnti-Mbp antibodyAnti-Mbp antibody |
Information sourced from Uniprot.org
