| Function | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf7AxotrophinMembrane-Associated Ring Finger Protein 7Membrane-Associated Ring-Ch Protein ViiMarch-ViiRing Finger Protein 177Ring-Type E3 Ubiquitin Transferase Marchf7 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf7 antibodyAnti-Axotrophin antibodyAnti-Membrane-Associated Ring Finger Protein 7 antibodyAnti-Membrane-Associated Ring-Ch Protein Vii antibodyAnti-March-Vii antibodyAnti-Ring Finger Protein 177 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf7 antibodyAnti-MARCHF7 antibodyAnti-AXOT antibodyAnti-MARCH7 antibodyAnti-RNF177 antibody |
Information sourced from Uniprot.org
