| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAP1B (1820-2100) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAP1B |
| Gene ID: |
4131 |
| Uniprot ID: |
MAP1B_HUMAN |
| Immunogen Region: |
1820-2100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1820-2100 of human MAP1B (NP_005900.2). |
| Immunogen Sequence: |
PPIDAASAEPYGFRASVLFD TMQHHLALNRDLSTPGLEKD SGGKTPGDFSYAYQKPEETT RSPDEEDYDYESYEKTTRTS DVGGYYYEKIERTTKSPSDS GYSYETIGKTTKTPEDGDYS YEIIEKTTRTPEEGGYSYDI SEKTTSPPEVSGYSYEKTER SRRLLDDISNGYDDSEDGGH TLGDPSYSYETTEKITSFPE SEGYSYETSTKTTRTPDTST YCYETAEKITRTPQASTYS |
| Post Translational Modifications | LC1 is generated from MAP1B by proteolytic processing. S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction. |
| Function | Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. |
| Protein Name | Microtubule-Associated Protein 1bMap-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionDendritic SpineColocalizes With Dapk1 In The Microtubules And Cortical Actin FibersMap1 Light Chain Lc1: Cytoplasm |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 1b antibodyAnti-Map-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 antibodyAnti-MAP1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
