| Host: | Mouse |
| Applications: | IHC-F/IHC-P/FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-LRP/MVP is suitable for use in Immunohistochemistry and Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | LMR5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | supernatant with 1% BSA and 0.1% sodium azide |
| Concentration: | 250 ug/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| Post Translational Modifications | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| Function | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| Protein Name | Major Vault Protein Mvp Lung Resistance-Related Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasm Nucleus Nuclear Pore Complex Perinuclear Region 5% Found In The Nuclear Pore Complex Translocates From The Nucleus To The Cytoplasm Upon Egf Treatment |
| Alternative Antibody Names | Anti-Major Vault Protein antibody Anti-Mvp antibody Anti-Lung Resistance-Related Protein antibody Anti-MVP antibody Anti-LRP antibody |
Information sourced from Uniprot.org