| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LPO (27-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LPO |
| Gene ID: |
4025 |
| Uniprot ID: |
PERL_HUMAN |
| Immunogen Region: |
27-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-280 of human LPO (NP_006142.1). |
| Immunogen Sequence: |
QTTRTSAISDTVSQAKVQVN KAFLDSRTRLKTAMSSETPT SRQLSEYLKHAKGRTRTAIR NGQVWEESLKRLRQKASLTN VTDPSLDLTSLSLEVGCGAP APVVRCDPCSPYRTITGDCN NRRKPALGAANRALARWLPA EYEDGLSLPFGWTPGKTRNG FPLPLAREVSNKIVGYLNEE GVLDQNRSLLFMQWGQIVDH DLDFAPDTELGSSEYSKAQC DEYCIQGDNCFPIMFPPND |
| Tissue Specificity | Mammary gland, milk and salivary gland. Found in bronchial submucosal glands. |
| Function | Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2. Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism. Shows antibacterial properties against Pseudomonas aeruginosa. The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro. Present in mammary and salivary gland secretions and may contribute to airway host defense against infection. May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation. |
| Protein Name | LactoperoxidaseLpoSalivary PeroxidaseSpo |
| Database Links | Reactome: R-HSA-8941413 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Lactoperoxidase antibodyAnti-Lpo antibodyAnti-Salivary Peroxidase antibodyAnti-Spo antibodyAnti-LPO antibodyAnti-SAPX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
