| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LILRA4 (240-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LILRA4 |
| Gene ID: |
23547 |
| Uniprot ID: |
LIRA4_HUMAN |
| Immunogen Region: |
240-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-450 of human LILRA4 (NP_036408.4). |
| Immunogen Sequence: |
LTLQCGSDVGYIRYTLYKEG ADGLPQRPGRQPQAGLSQAN FTLSPVSRSYGGQYRCYGAH NVSSEWSAPSDPLDILIAGQ ISDRPSLSVQPGPTVTSGEK VTLLCQSWDPMFTFLLTKEG AAHPPLRLRSMYGAHKYQAE FPMSPVTSAHAGTYRCYGSR SSNPYLLSHPSEPLELVVSG ATETLNPAQKKSDSKTAPHL QDYTVENLIRM |
| Tissue Specificity | Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells. |
| Function | Functions coreceptor to limit the innate immune responses to viral infections.signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4Cd85 Antigen-Like Family Member GImmunoglobulin-Like Transcript 7Ilt-7Cd Antigen Cd85g |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 antibodyAnti-Cd85 Antigen-Like Family Member G antibodyAnti-Immunoglobulin-Like Transcript 7 antibodyAnti-Ilt-7 antibodyAnti-Cd Antigen Cd85g antibodyAnti-LILRA4 antibodyAnti-ILT7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
