| Host: | Rabbit |
| Applications: | WB/IHC/ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Lipid Droplet-Associated Hydrolase is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 0.8 mg/mL |
| Dilution Range: | WB 1:500-1:2000, IHC 1:40-1:200 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | LDAH |
| Gene ID: | 60526 |
| Uniprot ID: | LDAH_HUMAN |
| Immunogen: | Synthetic peptide of human LDAH |
| Tissue Specificity | Present in macrophage-rich areas in atherosclerotic lesions (at protein level). Expressed in monocytes and monocyte-derived macrophages (at protein level). |
| Function | Probable serine lipid hydrolase associated with lipid droplets. Has low cholesterol esterase activity. Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis.has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages. |
| Protein Name | Lipid Droplet-Associated Hydrolase Lipid Droplet-Associated Serine Hydrolase Hldah |
| Cellular Localisation | Lipid Droplet Endoplasmic Reticulum Localizes To The Endoplasmic Reticulum In Absence Of Lipid Droplets And Translocates To Lipid Droplets Upon Lipid Storage Induction Lipid Droplet Localization Does Not Require Hydrolase Activity |
| Alternative Antibody Names | Anti-Lipid Droplet-Associated Hydrolase antibody Anti-Lipid Droplet-Associated Serine Hydrolase antibody Anti-Hldah antibody Anti-LDAH antibody Anti-C2orf43 antibody |
Information sourced from Uniprot.org