| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
LAMB1 |
| Gene ID: |
3912 |
| Uniprot ID: |
LAMB1_HUMAN |
| Immunogen Region: |
40-270 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-270 of human Laminin beta 1 (NP_002282.2). |
| Immunogen Sequence: |
GDLLIGRAQKLSVTSTCGLH KPEPYCIVSHLQEDKKCFIC NSQDPYHETLNPDSHLIENV VTTFAPNRLKIWWQSENGVE NVTIQLDLEAEFHFTHLIMT FKTFRPAAMLIERSSDFGKT WGVYRYFAYDCEASFPGIST GPMKKVDDIICDSRYSDIEP STEGEVIFRALDPAFKIEDP YSPRIQNLLKITNLRIKFVK LHTLGDNLLDSRMEIREKYY YAVYDMVVRGN |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. |
| Protein Name | Laminin Subunit Beta-1Laminin B1 ChainLaminin-1 Subunit BetaLaminin-10 Subunit BetaLaminin-12 Subunit BetaLaminin-2 Subunit BetaLaminin-6 Subunit BetaLaminin-8 Subunit Beta |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-373760Reactome: R-HSA-381426Reactome: R-HSA-8874081Reactome: R-HSA-8957275Reactome: R-HSA-9619665 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMajor Component |
| Alternative Antibody Names | Anti-Laminin Subunit Beta-1 antibodyAnti-Laminin B1 Chain antibodyAnti-Laminin-1 Subunit Beta antibodyAnti-Laminin-10 Subunit Beta antibodyAnti-Laminin-12 Subunit Beta antibodyAnti-Laminin-2 Subunit Beta antibodyAnti-Laminin-6 Subunit Beta antibodyAnti-Laminin-8 Subunit Beta antibodyAnti-LAMB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
