| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KLHL41 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLHL41 |
| Gene ID: |
10324 |
| Uniprot ID: |
KLH41_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KLHL41 (NP_006054.2). |
| Immunogen Sequence: |
MDSQRELAEELRLYQSTLLQ DGLKDLLDEKKFIDCTLKAG DKSLPCHRLILSACSPYFRE YFLSEIDEAKKKEVVLDNVD PAILDLIIKYLYSASIDLND GNVQDIFALASRFQIPSVFT VCVSYLQKRLAPGNCLAILR LGLLLDCPRLAISAREFVSD RFVQICKEEDFMQLSPQELI SVISNDSLNVEKEEAVFEAV MKWVRTDKENRVKNLSEVFD CIRFRLMTEKYFKDHVEKD |
| Tissue Specificity | Sarcomeric muscle. |
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. |
| Function | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. |
| Protein Name | Kelch-Like Protein 41Kel-Like Protein 23Kelch Repeat And Btb Domain-Containing Protein 10Kelch-Related Protein 1Sarcosin |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPseudopodiumRuffleMyofibrilSarcomereM LineSarcoplasmic Reticulum MembraneEndoplasmic Reticulum MembranePredominantly Cytoplasmic But Can Colocalize With F-Actin At The Membrane Ruffle-Like Structures At The Tips Of Transformation-Specific Pseudopodia |
| Alternative Antibody Names | Anti-Kelch-Like Protein 41 antibodyAnti-Kel-Like Protein 23 antibodyAnti-Kelch Repeat And Btb Domain-Containing Protein 10 antibodyAnti-Kelch-Related Protein 1 antibodyAnti-Sarcosin antibodyAnti-KLHL41 antibodyAnti-KBTBD10 antibodyAnti-KRP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89098/357557/STJ11100026_1__69013.1713121681.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
