| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process. |
| Protein Name | Kelch Domain-Containing Protein 3Testis Intracellular Mediator Protein |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Kelch Domain-Containing Protein 3 antibodyAnti-Testis Intracellular Mediator Protein antibodyAnti-KLHDC3 antibodyAnti-PEAS antibody |
Information sourced from Uniprot.org
