| Tissue Specificity | In 8.5 day embryos, expressed in midbrain, anterior hindbrain and ventral forebrain. In 9 day embryos, expressed throughout ventral anterior half of embryo including midbrain-hindbrain junction, ventral midbrain, diencephalon and forebrain. At 10.5 days, distribution is more widespread with expression also found in developing limb buds. Widely expressed in the adult. |
| Post Translational Modifications | Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-197 is the major site. |
| Function | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. |
| Protein Name | Krueppel-Like Factor 3Basic Krueppel-Like FactorCaccc-Box-Binding Protein BklfTef-2 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 3 antibodyAnti-Basic Krueppel-Like Factor antibodyAnti-Caccc-Box-Binding Protein Bklf antibodyAnti-Tef-2 antibodyAnti-Klf3 antibodyAnti-Bklf antibody |
Information sourced from Uniprot.org
