| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLF3 |
| Gene ID: | 51274 |
| Uniprot ID: | KLF3_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KLF3 (NP_057615.3). |
| Immunogen Sequence: | MLMFDPVPVKQEAMDPVSVS YPSNYMESMKPNKYGVIYST PLPEKFFQTPEGLSHGIQME PVDLTVNKRSSPPSAGNSPS SLKFPSSHRRASPGLSMPSS SPPIKKYSPPSPGVQPFGVP LSMPPVMAAALSRHGIRSPG ILPVIQPVVVQPVPFMYTSH LQQPLMVSLSEEMENSSSSM QVPVIESYEKPISQKKIKIE PGIEPQRTDYYPEEMSPPLM NSVSPPQALLQENHPSVIV |
| Post Translational Modifications | Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site. |
| Function | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. |
| Protein Name | Krueppel-Like Factor 3Basic Krueppel-Like FactorCaccc-Box-Binding Protein BklfTef-2 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 3 antibodyAnti-Basic Krueppel-Like Factor antibodyAnti-Caccc-Box-Binding Protein Bklf antibodyAnti-Tef-2 antibodyAnti-KLF3 antibodyAnti-BKLF antibody |
Information sourced from Uniprot.org